USP19

1. USP19 increases bone mineral content in mice.

   “Bone mineral content was decreased in the USP19 KO bone, more evidently in cortical bone than in trabecular bone and only in males.”

   Animalsknockoutbonemales

   Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jun 2, 2026

More on Bone mineral content

1. USP19 impairs glucose tolerance in mice.

   “Glucose tolerance was also improved in these older adult USP19 KO mice, but only in females.”

   Animalsknockoutfemales

   Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jun 2, 2026

1. USP19 raises the risk of obesity in mice.

   “loss of USP19 is protective against loss of muscle mass and obesity in mice aged 22-24 months”

   Animalsknockout

   Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jun 2, 2026

More on Obesity

1. USP19 raises the risk of sarcopenia in mice.

   “loss of USP19 is protective against loss of muscle mass and obesity in mice aged 22-24 months”

   Animalsknockout

   Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jun 2, 2026

More on Sarcopenia