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ung-1

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: H2020 European Research Council and 2 more
  • Model organisms1

Effects

2

Lifespan

upin worms1

1 study

  1. ung-1 extends lifespan in worms.

    “Genetic ablation of either of the two DNA glycosylases found in C. elegans, NTH-1 and UNG-1, improved mitochondrial function, lifespan, and memory impairment.”

    Model organismsin a pro-aggregate tau C. elegans model

    Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy

    Nucleic acids researchAug 16, 2024

Memory impairment

upin worms1

1 study

  1. ung-1 improves memory impairment in worms.

    “Genetic ablation of either of the two DNA glycosylases found in C. elegans, NTH-1 and UNG-1, improved mitochondrial function, lifespan, and memory impairment.”

    Model organismsin a pro-aggregate tau C. elegans model

    Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy

    Nucleic acids researchAug 16, 2024

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