UNC45B

There are 2 papers on UNC45B in aging research: none in people yet, 2 in animals. The newest story, Oct 30, 2026: “Reducing a muscle protein weakened mice before muscle loss”.

Gene

2 papers study it2 findings

HGNCNCBI GeneTaxon

See all 2

None of its findings points the other way.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals2

Effects

2

Non-rapid eye movement sleep

downin mice1

1 study
  1. UNC45B decreases non-rapid eye movement sleep in mice (Unc45b imKO).

    “Unc45b imKO mice reduced the amount of deeper non-rapid eye movement sleep, locomotor activity, and body temperature during the sleep phase.”

    AnimalsUnc45b imKO

    Reducing a muscle protein weakened mice before muscle loss

    Aging cell

Plantar flexor torque

downin mice1

1 study
  1. UNC45B decreases plantar flexor torque in mice (AAV-mediated knockdown).

    “Unc45b in 3-month-old mouse triceps surae muscle first reduced plantar flexor torque and then decreased gastrocnemius muscle mass.”

    AnimalsAAV-mediated knockdowntriceps surae muscle

    Reducing a muscle protein weakened mice before muscle loss

    Aging cell

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
Aging Cell

Reducing a muscle protein weakened mice before muscle loss

Experiments in 3-month-old male mice found that reducing the protein lowered muscle force before muscle mass declined over eight weeks.Experiments in 3-month-old male mice found that reducing the protein lowered muscle force before muscle mass declined over eight weeks.

Mouse studyMuscle