SPPL2B

SPPL2B increases age-associated synaptic proteomic changes in mice.

“SPPL2b deletion also attenuated age-associated proteomic changes in synaptic pathways”

Animalsshown by constitutive Sppl2b deletion versus wild-typecortex and hippocampus

Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging

bioRxiv (Cold Spring Harbor Laboratory)·28 Jul 2026Preprint