SOAT2

1. SOAT2 impairs anti-tumor immunity.

   “leading to enhanced Treg suppresser functions but reduced CD8+ T cell proliferation, migration, homeostasis and anti-tumor immunity.”

   Animalsoverexpression in Treg cells

   Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

   Nature communications·Jan 13, 2025

1. SOAT2 increases lipid and ceramide metabolism.

   “SOAT2 overexpression in Treg cells promotes cholesterol metabolism by activating the SREBP2-HMGCR-GGPP pathway”

   Animalsin Treg cells

   Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

   Nature communications·Jan 13, 2025

More on Lipid and ceramide metabolism

1. SOAT2 is associated with poor prognosis in humans.

   “radiomics analysis of LSCC patients associates increased SOAT2 expression with reduced immune infiltration and poor prognosis.”

   Humansin Treg cells in LSCC patients

   Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

   Nature communications·Jan 13, 2025

1. SOAT2 is associated with immune infiltration in humans.

   “radiomics analysis of LSCC patients associates increased SOAT2 expression with reduced immune infiltration and poor prognosis.”

   Humansin Treg cells in LSCC patients

   Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

   Nature communications·Jan 13, 2025