SLC7A14
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: China Postdoctoral Science Foundation and 1 more
- Animals1
- Cells1
Effects
3mTOR signaling
downin mice1
1 study
mTOR signaling
downin mice1
SLC7A14 inhibits mTOR signaling in mice.
“SLC7A14 regulates the intestinal sympathetic afferent nerves by inhibiting mTORC1 signaling through inhibiting TSC1 phosphorylation”
Animalsin aged micemales
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice
Nature communications
Lipolysis impairment
downin mice1
1 study
Lipolysis impairment
downin mice1
SLC7A14 protects against lipolysis impairment in mice.
“SLC7A14 deletion mimics the age-induced lipolysis impairment”
Animalsshown by deletion in POMC neuronswhite adipose tissuemales
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice
Nature communications
Lipolysis
upin mice1
1 study
Lipolysis
upin mice1
SLC7A14 improves lipolysis in mice.
“Overexpression of SLC7A14 in POMC neurons alleviates the aging-reduced lipolysis”
Animalsin POMC neurons of aged micewhite adipose tissuemales
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice
Nature communications
Upstream
1SIRT6
downin human cells1
1 study
SIRT6
downin human cells1
SIRT6 decreases SLC7A14 in human cells.
“Solute carrier transporter SLC7A14 was silenced by SIRT6”
Cellsumbilical vein
Novel transcriptional functions and interaction partners for the Sirtuin family
Zenodo (CERN European Organization for Nuclear Research)Preprint