SLC16A5

Gene

1 paper studies it3 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 1

None of its findings points the other way.

1 lab in 2 countries

3 of 3 findings with company ties

Animals1

Effects

Body weight loss

is required forin mice1

1 study

SLC16A5 is required for body weight loss in mice.
“High-fat-diet-fed mice with global or intestinal epithelial-specific deletion of MCT6 exhibit resistance to metformin-associated weight loss.”
Animalsmetformin treatment in high-fat-diet-fed mice; shown by global or intestinal epithelial-specific deletionintestine
Mice lacking a gut protein resist metformin-associated weight loss
CellOct 22, 2026

Circulating N-lactoyl-phenylalanine

is required forin mice1

1 study

SLC16A5 is required for circulating N-lactoyl-phenylalanine in mice.
“is required for maintaining normal circulating Lac-Phe levels in vivo, particularly following metformin treatment or high-intensity exercise.”
Animalsparticularly following metformin treatment or high-intensity exercise
Mice lacking a gut protein resist metformin-associated weight loss
CellOct 22, 2026

More on Circulating N-lactoyl-phenylalanine

N-lactoyl-phenylalanine efflux

mediatesin mouse cells1

1 study

SLC16A5 mediates N-lactoyl-phenylalanine efflux in mouse cells.
“MCT6 transports Lac-Phe in vitro, mediates Lac-Phe efflux in cells”
Cells
Mice lacking a gut protein resist metformin-associated weight loss
CellOct 22, 2026

Latest

1 paper in 12 months

CellOct 24

Mice lacking a gut protein resist metformin-associated weight loss

Mice fed a high-fat diet resisted metformin-associated weight loss when they lacked a protein that releases an appetite-suppressing molecule from intestinal cells.Mice fed a high-fat diet resisted metformin-associated weight loss when they lacked a protein that releases an appetite-suppressing molecule from intestinal cells.

Mouse studyGut and microbiome

Paper

SLC16A5

Effects

Latest

Mice lacking a gut protein resist metformin-associated weight loss

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