Circulating N-lactoyl-phenylalanine

Biomarker

1 paper studies it1 finding

1 new paper in 30 daysSee all 1

  • Animals1

Upstream

1

SLC16A5

is required forin mice1

1 study
  1. SLC16A5 is required for circulating N-lactoyl-phenylalanine in mice.

    “is required for maintaining normal circulating Lac-Phe levels in vivo, particularly following metformin treatment or high-intensity exercise.”

    Animalsparticularly following metformin treatment or high-intensity exercise

    Mice lacking a gut protein resist metformin-associated weight loss

    Cell

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Cell

Mice lacking a gut protein resist metformin-associated weight loss

Mice fed a high-fat diet resisted metformin-associated weight loss when they lacked a protein that releases an appetite-suppressing molecule from intestinal cells.Mice fed a high-fat diet resisted metformin-associated weight loss when they lacked a protein that releases an appetite-suppressing molecule from intestinal cells.