AgingResearch.NewsJoin free

RS4244620

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Alzheimer’s Research UK and 4 more
  • Humans1

Associations

2

Cognitive function

downin humans1

1 study

  1. RS4244620 is associated with cognitive function in humans (p ≤ 0.04).

    “Additionally, rs4244620 was nominally associated with lower cognition, faster slopes of cognitive decline, and greater Parkinsonian signs”

    Humansn ~ 1700 ROSMAP with SNP/phenotypic datan = 1,700

    Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci

    EpigeneticsAug 22, 2024

Cortical age

upin humans1

1 study

  1. RS4244620 is associated with cortical age in humans (p = 1.29 × 10−7).

    “In the meta-analysis, the strongest association was rs4244620 (p = 1.29 × 10−7), which also exhibited FDR-significant cis-eQTL effects for CD46”

    Humansmeta-analysis of ROSMAP and Brains for Dementia Researchcortex

    Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci

    EpigeneticsAug 22, 2024

More on Cortical age

Latest

Related