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RNASE4

Gene

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Glenn Foundation for Medical Research and 4 more
  • Cells1

Effects

2

Senescent fibroblast survival

upin human cells1

1 study

  1. RNASE4 increases senescent fibroblast survival in human cells.

    “MDM2 and RNASE4 transcription is also elevated in human senescent fibroblasts to restrain p53 and promote survival.”

    Cellssenescent cellsfibroblast

    Senescent cells limit p53 activity via multiple mechanisms to remain viable

    Nature communications

p53-mediated apoptosis

downin mouse cells1

1 study

  1. RNASE4 inhibits p53-mediated apoptosis in mouse cells.

    “Of these, Mdm2, Rnase4, and Ang act by suppressing p53-mediated apoptosis through various mechanisms that are also engaged in response to DNA damage.”

    Cellssenescent cells; shown through gene knockdownembryonic fibroblast

    Senescent cells limit p53 activity via multiple mechanisms to remain viable

    Nature communications

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