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PUS10

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Effects

1

Hematopoietic stem cell function

downin mice1

1 study

  1. PUS10 impairs hematopoietic stem cell function in mice.

    “enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC”

    Animalsenforced protein expressionhematopoietic stem cells

    Aging-induced pseudouridine synthase 10 impairs hematopoietic stem cells

    HaematologicaMay 11, 2023

Associations

1

Hematopoietic homeostasis

mixedin mice1

1 study

  1. PUS10 is associated with hematopoietic homeostasis in mice.

    “aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function”

    Animalsshown by knockouthematopoietic stem cells

    Aging-induced pseudouridine synthase 10 impairs hematopoietic stem cells

    HaematologicaMay 11, 2023

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