PTPN23

1. PTPN23 increases insulin/IGF-1 signalling in mouse cells.

   “Defects in insulin-stimulated signaling were apparent in differentiated PTPN23 knockout adipocytes”

   Cellsinsulin stimulation; shown by PTPN23 knockoutdifferentiated adipocyte

   HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 3, 2022Preprint

More on Insulin/IGF-1 signalling

1. PTPN23 increases adipogenesis in mouse cells.

   “PTPN23 knockout preadipocytes similarly display reduced adipogenesis in vitro.”

   Cellsshown by PTPN23 knockoutpreadipocyte

   HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 3, 2022Preprint

1. PTPN23 protects against lipodystrophy in mice.

   “PTPN23 H/H mice developed into adulthood but had reduced size, lipodystrophy, and shortened lifespan.”

   Animalsshown by hypomorphic PTPN23 H/H alleles

   HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 3, 2022Preprint

More on Lipodystrophy