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PSG4

Gene

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funder: National Natural Science Foundation of China
  • Humans1
  • Cells1

Effects

1

Cellular senescence

mediatesin human cells1

1 study

  1. PSG4 mediates cellular senescence in human cells.

    “Gain- and loss-of-function studies suggested that PSG4 regulated cellular senescence.”

    Cellsdental pulp

    Molecular changes of cellular senescence in dental pulp stem cells during in vitro culture: A potential role of PSG4

    Tissue & cellJan 26, 2025

More on Cellular senescence

Associations

2

Cellular senescence

upin human cells1

1 study

  1. Cellular senescence is associated with PSG4 in human cells.

    “PSG4 expression levels were significantly elevated during cellular senescence”

    Cellsdental pulp

    Molecular changes of cellular senescence in dental pulp stem cells during in vitro culture: A potential role of PSG4

    Tissue & cellJan 26, 2025

More on Cellular senescence

Spontaneous preterm labor

upin humans1

1 study

  1. Spontaneous preterm labor is associated with PSG4 in humans.

    “pregnancy-specific beta-1-glycoprotein 4 (PSG4), a potent molecular driver for cellular aging, was significantly increased in preterm placentas (N = 30) compared to their full-term counterparts (N = 9).”

    Humanspreterm versus full-term placentasplacenta

    Novel Placental Biomarker Shows Predictive Potential for Spontaneous Preterm Labor

    American journal of perinatologyNov 29, 2024

More on Spontaneous preterm labor

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