Cells
Blocking ribosome production caused kidney scarring in mice
In mouse experiments, a drug that blocked production of cells’ protein-making machinery caused kidney scarring before kidney function declined.In mouse experiments, a drug that blocked production of cells’ protein-making machinery caused kidney scarring before kidney function declined.
Mouse studyKidney
Who was studiedMale C57BL/6 mice, 3 weeks, against vehicle control
What changedMice treated with CX5461 developed renal fibrosis compared to vehicle control
The catchCX5461 can induce DNA damage independently of RNA Pol I inhibition