What does the research say about Phf2?

Phf2

There are 3 papers on Phf2 in aging research: none in people yet, 3 in animals. The newest story, Nov 3, 2026: “Protein loss increases bone loss in an animal model”.

Gene

3 papers study it2 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 3 papers on Phf2

At a glance

The findings reach cells, none yet in people. 1 lab.

None of its findings points the other way.

1 lab

Funder: National Research Foundation of Korea

Animals3

Effects

NFATC1 ubiquitination and proteasomal degradation

upin cells1

1 study

Phf2 increases NFATC1 ubiquitination and proteasomal degradation in cells (HUWE1-dependent; facilitated by K612 hydroxylation).
“PHF2 directly associated with NFATc1 and catalyzed K612 hydroxylation in vitro, facilitating HUWE1-dependent ubiquitination and proteasomal degradation of NFATc1.”
CellsHUWE1-dependent; facilitated by K612 hydroxylation
Protein loss increases bone loss in an animal model
Cell death discoveryNov 3, 2026

osteoclast differentiation

downin cells1

1 study

Phf2 inhibits osteoclast differentiation in cells (PHF2 gain-of-function).
“Conversely, PHF2 gain-of-function suppressed osteoclast differentiation.”
CellsPHF2 gain-of-functionosteoclast
Protein loss increases bone loss in an animal model
Cell death discoveryNov 3, 2026

Latest

1 paper in 12 months

Cell Death DiscoveryNov 3

Protein loss increases bone loss in an animal model

Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.Removing PHF2 from certain bone marrow-derived cells increased bone-resorbing cell formation and deterioration of the spongy tissue inside bones.

Animal studyBones and joints