pfd-6

1. pfd-6 increases DAF-16 transcriptional activity in worms.

   “PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity.”

   Model organisms

   Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

   Genes & development·Nov 26, 2018

More on DAF-16 transcriptional activity

1. pfd-6 is required for lifespan extension in worms.

   “We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis.”

   Model organismsunder reduced insulin/IGF-1 signalingintestine and hypodermis

   Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

   Genes & development·Nov 26, 2018