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pas-1

Gene

1 paper studies it3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Ministry of Science and ICT, South Korea and 3 more
  • Model organisms1

Effects

3

Intestinal atrophy

downin worms1

1 study

  1. pas-1 protects against intestinal atrophy in worms.

    “RNAi of pas-1 and pas-3 promoted intestinal atrophy and colonization”

    Model organismsshown by RNAi

    Caffeine-Induced Upregulation of pas-1 and pas-3 Enhances Intestinal Integrity by Reducing Vitellogenin in Aged Caenorhabditis elegans Model

    Nutrients

Lifespan

is required forin worms1

1 study

  1. pas-1 is required for lifespan in worms.

    “this effect was not observed by pas-1 but not pas-3 RNAi”

    Model organismscaffeine treatment

    Caffeine-Induced Upregulation of pas-1 and pas-3 Enhances Intestinal Integrity by Reducing Vitellogenin in Aged Caenorhabditis elegans Model

    Nutrients

Vitellogenin production

downin worms1

1 study

  1. pas-1 inhibits vitellogenin production in worms.

    “They reduced VIT production by repressing unc-62, a transcriptional activator of vit expression.”

    Model organismsaged

    Caffeine-Induced Upregulation of pas-1 and pas-3 Enhances Intestinal Integrity by Reducing Vitellogenin in Aged Caenorhabditis elegans Model

    Nutrients

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