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mir-275

Gene

1 paper studies it3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Model organisms1

Effects

2

Dredd

downin flies1

1 study

  1. mir-275 inhibits Dredd in flies.

    “miR-275 further inhibits the expression of Dredd through binding to its 3'UTR to negatively control Drosophila Imd immune response.”

    Model organismsthrough binding to its 3'UTR

    The Relish/miR-275/Dredd mediated negative feedback loop is crucial to restoring immune homeostasis of Drosophila Imd pathway

    Insect biochemistry and molecular biology

More on Dredd

Lifespan

downin flies1

1 study

  1. mir-275 shortens lifespan in flies.

    “Remarkably, the ectopic expression of miR-275 significantly reduces Drosophila lifespan.”

    Model organismsectopic expression

    The Relish/miR-275/Dredd mediated negative feedback loop is crucial to restoring immune homeostasis of Drosophila Imd pathway

    Insect biochemistry and molecular biology

Upstream

1

Rel

upin flies1

1 study

  1. Rel activates mir-275 in flies.

    “Relish may directly activate the transcription of miR-275 via binding to its promoter in vitro and vivo”

    Model organismsvia binding to promoter

    The Relish/miR-275/Dredd mediated negative feedback loop is crucial to restoring immune homeostasis of Drosophila Imd pathway

    Insect biochemistry and molecular biology

More on Rel

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