What does the research say about miR-143/-145cluster?

miR-143/-145cluster

There is 1 paper on miR-143/-145cluster in aging research: none in people yet, 1 in animals. The newest story, Oct 31, 2026: “Disrupting two small RNAs impaired heart repair in zebrafish”.

Gene

1 paper studies it2 findings

Taxon

1 new paper in 30 daysSee all 1

None of its findings points the other way.

1 lab

Animals1

Effects

Cardiomyocyte cell-cycle activity

upin zebrafish1

1 study

miR-143/-145cluster increases cardiomyocyte cell-cycle activity in zebrafish following cryoinjury; shown by double knockout.
“miR-zdKO mutants also showed significantly reduced CM cell-cycle activity”
Animalsfollowing cryoinjury; shown by double knockoutcardiomyocyte
Disrupting two small RNAs impaired heart repair in zebrafish
Frontiers in cell and developmental biologyOct 30, 2026

Residual cardiac scar area

downin zebrafish1

1 study

miR-143/-145cluster decreases residual cardiac scar area in zebrafish following cryoinjury; shown by double knockout.
“miR-zdKO mutants exhibited significantly larger residual scar areas at 90 days post injury, demonstrating failure to resolve the injury scar.”
Animalsfollowing cryoinjury; shown by double knockoutheart90 days post injury
Disrupting two small RNAs impaired heart repair in zebrafish
Frontiers in cell and developmental biologyOct 30, 2026

Latest

1 paper in 12 months

Frontiers in Cell and Developmental BiologyOct 30

Disrupting two small RNAs impaired heart repair in zebrafish

After heart injury, adult zebrafish lacking two small RNAs retained larger scars at 90 days than fish without the disruptions.After heart injury, adult zebrafish lacking two small RNAs retained larger scars at 90 days than fish without the disruptions.

Accepted, not yet published: fish studyMechanisms

Paper

miR-143/-145cluster

Effects

Latest

Disrupting two small RNAs impaired heart repair in zebrafish

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