MBNL2
1 paper2 findings
- 1 lab in 1 country
- Funder: National Institutes of Health
- Animals1
Effects
2Cellular senescence
upin cells1
1 study
Cellular senescence
upin cells1
MBNL2 induces cellular senescence in cells.
“Additionally, the inhibition of TGF-β1/SMAD3 signaling attenuated the impact of over-expression of MBNL2 in inducing senescence and cardiac fibrosis.”
Cellsshown by MBNL2 over-expression
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4
iScienceJun 3, 2024
Cardiac fibrosis
upin cells1
1 study
Cardiac fibrosis
upin cells1
MBNL2 increases cardiac fibrosis in cells.
“MBNL2, by orchestrating SUMOylation of KLF4, upregulating the TGF-β1/SMAD3 signaling pathway, emerges as a significant promoter of aging-related cardiac fibrosis.”
Cellsshown by MBNL2 inhibitionheart
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4
iScienceJun 3, 2024
Latest
iScience
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4
Experiments in animalsMechanisms