There is 1 paper on LINC-ASEN in aging research: none in people yet, 1 in cells.
1 paper studies it2 findings
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
Cells and mice: a single group. Worms or flies and humans: nothing yet.
- 1 lab in 1 country
- Funders: Daegu Gyeongbuk Institute of Science and Technology and 5 more
- Cells1
Effects
1CDKN1A
downin human cells1
1 study
CDKN1A
downin human cells1
LINC-ASEN decreases CDKN1A in complex with UPF1.
“reducing p21 production transcriptionally and posttranscriptionally”
Cellsin complex with UPF1
Cell death and differentiation
Associations
1P21 mRNA
downin mice1
1 study
P21 mRNA
downin mice1
LINC-ASEN is associated with P21 mRNA in tumors, human cancer tissues and aged mouse tissues.
“Linc-ASEN levels were found to correlate inversely with p21 mRNA levels in tumors from patient-derived mouse xenograft, in various human cancer tissues, and in aged mice tissues”
Animalsin tumors, human cancer tissues and aged mouse tissuestumor
Cell death and differentiation
Latest
Cell Death and Differentiation
A novel long noncoding RNA Linc-ASEN represses cellular senescence through multileveled reduction of p21 expression
Experiments in human cellsEpigenetic regulation of gene expression