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linc-133

Gene

1 paper studies it3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Henan University
  • Model organisms1

Effects

3

Aggregated proteins

downin worms1

1 study

  1. linc-133 decreases aggregated proteins in worms.

    “linc-133 gain of function can induce HSP chaperones to select and process the aggregated proteins for degradation through ubiquitination”

    Model organismsdaf-18 loss / protein phosphatase dysfunction

    Gain of function in linc-133 compensates for daf-18/PTEN loss and rescues survival

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Aggregated proteins

DAF-16 nuclear export

downin worms1

1 study

  1. linc-133 inhibits DAF-16 nuclear export in worms.

    “linc-133 gain of function interacts with 14-3-3 proteins to obstruct DAF-16 translocation from the nucleus to the cytoplasm”

    Model organismsdefective lipid phosphatase activity of DAF-18

    Gain of function in linc-133 compensates for daf-18/PTEN loss and rescues survival

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

Lifespan

upin worms1

1 study

  1. linc-133 extends lifespan in worms.

    “linc-133 gain of function can fully restore the shortened survival caused by daf-18 loss”

    Model organismsdaf-18 loss

    Gain of function in linc-133 compensates for daf-18/PTEN loss and rescues survival

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

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