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Lgr4

Gene

2 papers3 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Harbin Institute of Technology and 2 more
  • Model organisms2

Effects

2

Male reproductive success

upin flies2

2 studies

  1. Lgr4 improves male reproductive success in flies.

    “Adult-specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity.”

    Model organismsadult glia-specific knockdownmales

    Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

    Journal of neuroscience research1 Jan 2024

  2. Lgr4 increases male reproductive success in flies.

    “Adult-specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity.”

    Model organismsshown by adult-specific glial Lgr4 knockdownglial cellmales

    Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

    bioRxiv (Cold Spring Harbor Laboratory)7 Oct 2022Preprint

Early development

is required forin flies1

1 study

  1. Lgr4 is required for early development in flies.

    “Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan.”

    Model organismsshown by glial Lgr4 knockdownglial cell

    Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

    bioRxiv (Cold Spring Harbor Laboratory)7 Oct 2022Preprint

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