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KCNK9

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Animal Science and 3 more
  • Cells1

Effects

2

Cell swelling response

downin bovine cells1

1 study

  1. KCNK9 decreases cell swelling response in bovine cells.

    “The cell swelling response to exposure to a hypotonic solution (200 mOsm/L) was highly reduced in TASK-3-overexpressing cells compared to vector-transfected cells.”

    Cellshypotonic exposure (200 mOsm/L)

    Downregulation of TASK-3 Channel Induces Senescence of Granulosa Cells in the Bovine Follicular Cystic Ovary

    Preprints.org22 Jan 2024Preprint

Cellular senescence

downin bovine cells1

1 study

  1. KCNK9 protects against cellular senescence in bovine cells.

    “TASK-3-knockdown cells showed arrested growth. Senescence markers were detected in LFGCs and TASK-3-knockdown cells.”

    CellsTASK-3 knockdown in granulosa cells

    Downregulation of TASK-3 Channel Induces Senescence of Granulosa Cells in the Bovine Follicular Cystic Ovary

    Preprints.org22 Jan 2024Preprint

More on Cellular senescence

Upstream

1

Bovine follicular cystic ovary

downin bovine cells1−50%

1 study

  1. Bovine follicular cystic ovary decreases KCNK9 in bovine cells (approximately 50%).

    “TASK-3 expression levels significantly decreased by approximately 50% in both LF and granulosa cells obtained from LF (LFGCs) compared to the corresponding controls.”

    Cellsin bovine large follicular cysts / LFGCsgranulosa cells

    Downregulation of TASK-3 Channel Induces Senescence of Granulosa Cells in the Bovine Follicular Cystic Ovary

    Preprints.org22 Jan 2024Preprint

More on Bovine follicular cystic ovary

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