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ints-4

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Canada Foundation for Innovation and 4 more
  • Model organisms1

Effects

1

Lifespan

no changein worms1downin worms1

1 study

  1. ints-4 has no effect on lifespan in worms.

    “becomes dispensable for development and lifespan after the animals have reached the L2/L3 stage”

    Model organismsdepletion after L2/L3 stage

    Differential effect of ubiquitous and germline depletion of Integrator complex function on C. elegans physiology

    Biology open12 Mar 2025

  2. ints-4 shortens lifespan in worms.

    “Depletion of INTS-4 only shortened lifespan if auxin was introduced at the L1 stage”

    Model organismsubiquitous INTS-4 depletion at L1 stage

    Differential effect of ubiquitous and germline depletion of Integrator complex function on C. elegans physiology

    Biology open12 Mar 2025

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