Genes
Cholesterol links to dementia varied by genetic region
A human genetic analysis examined four blood fat traits and seven brain outcomes, finding that some links changed when researchers excluded one gene region.A human genetic analysis examined four blood fat traits and seven brain outcomes, finding that some links changed when researchers excluded one gene region.
Mendelian randomizationMechanisms
Who was studiedParticipants of European ancestry
What changedThe total cholesterol–dementia association weakened from an odds ratio of 1.255 to 1.022 after excluding APOE-region variants
The catchGenetic overlap among lipid traits can bias estimates attributed to cholesterol