idha-1

1. idha-1 increases repressive histone marks H3K27me3 and H3K9me3 in worms.

   Model organismsShown by idha-1 depletion

   Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint

Repressive histone marks H3K27me3 and H3K9me3 →

1. idha-1 inhibits germ cell-to-neuron direct reprogramming in worms.

   Model organismsShown by RNAi-mediated idha-1 depletion with ectopic CHE-1 expressiongermline

   Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint