HFE

1. HFE has no effect on vertebral fracture in humans (OR 0.99, 95% CI 0.53-1.87).

   “No excess fracture risk was observed in female C282Y homozygotes (n=23/138, 16.7%) vs those without HFE alleles (n=24/144, 16.7%); OR: 0.99, 95%CI: 0.53-1.87, p=1.00.”

   HumansC282Y homozygosityvertebrafemalesn = 282

   Radiographically identified vertebral fractures in haemochromatosis-associated HFE C282Y homozygotes in the UK Biobank · medRxiv · 22 Aug 2026 · Preprint

Vertebral fracture →

1. HFE is associated with vertebral fracture in humans (OR 2.95, 95% CI 1.28-6.85).

   “Male C282Y homozygotes had increased odds of vertebral fracture (n=22/89, 24.7%) compared to participants without HFE alleles (n=9/90, 10.0%); Odds Ratio [OR]: 2.95, 95%CI: 1.28-6.85, p=0.01.”

   HumansC282Y homozygosityvertebramales

   Radiographically identified vertebral fractures in haemochromatosis-associated HFE C282Y homozygotes in the UK Biobank · medRxiv · 22 Aug 2026 · Preprint

Vertebral fracture →