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H-2

Gene

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Animals2

Effects

1

Lifespan

downin mice1

1 study

  1. H-2 shortens lifespan in mice (602 vs 689 days).

    “F2 and backcross progeny homozygous for the H-2 allele of B10.F had a mean age at death (602 days) significantly reduced from that of progeny homozygous for the H-2 allele of B10 (689 days).”

    Animalsin F2 and backcross progeny

    Interaction of H-2 genotype and basal serum immunoglobulin A level influences longevity

    Mechanisms of ageing and developmentSep 1, 1986

Associations

1

Excision repair of UV-induced DNA damage

upin mice1

1 study

  1. H-2 is associated with excision repair of UV-induced DNA damage in mice.

    “the level of DNA repair of UV-induced damage corresponded to the H-2 allele (H-2d/2d from NZB or H-2b/2b from CBA) inherited from the parental strain”

    Animalsin (NZB X CBA)F2 hybrid adult progenysplenic lymphocytes

    DNA repair, H-2, and aging in NZB and CBA mice

    Tissue antigensJan 1, 1981

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