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GPER

Gene

3 papers study it2 findings

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: National Heart, Lung, and Blood Institute and others
  • Animals3

Effects

2

Endothelial function

upin mice1

1 study

  1. GPER improves endothelial function in mice.

    “GPER deletion abrogated these sex differences and significantly reduced endothelial function in adult female mice.”

    Animalsadult micefemales

    Sex differences in vascular aging and impact of GPER deletion

    American journal of physiology. Heart and circulatory physiology

Myocardial ECE-2 and ETB receptor mRNA expression

upin mice1

1 study

  1. GPER increases myocardial ECE-2 and ETB receptor mRNA expression in mice (Gper deletion reduced ECE-2 and ETB receptor mRNA by 57% and 40%, respectively, versus wild-type mice).

    “Deletion of Gper inhibited the age-dependent increase in ECE-2 and ETB receptor mRNA levels (57% and 40% reduction, respectively, each p<0.01 vs. wild-type mice)”

    Animalsshown by Gper deletion during agingleft ventricular myocardium

    GPER is required for the age-dependent upregulation of the myocardial endothelin system

    Life sciences

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