Myocardial ECE-2 and ETB receptor mRNA expression

1. GPER increases myocardial ECE-2 and ETB receptor mRNA expression in mice (Gper deletion reduced ECE-2 and ETB receptor mRNA by 57% and 40%, respectively, versus wild-type mice).

   “Deletion of Gper inhibited the age-dependent increase in ECE-2 and ETB receptor mRNA levels (57% and 40% reduction, respectively, each p<0.01 vs. wild-type mice)”

   Animalsshown by Gper deletion during agingleft ventricular myocardium

   GPER is required for the age-dependent upregulation of the myocardial endothelin system

   Life sciences·Feb 13, 2016

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