What does the research say about FOXO3GENOTYPE?

FOXO3GENOTYPE

There is 1 paper on FOXO3GENOTYPE in aging research: 1 observational study in people. The newest story, Nov 2, 2026: “Gene variant linked to lower lung cancer risk in former smokers”.

Gene

1 paper studies it2 findings

See all 1 papers on FOXO3GENOTYPE

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“Among former smokers, FOXO3-G carriers had a lower risk than FOXO3-TT carriers (LC: HR, 0.42; 95% CI, 0.23-0.79”

Longevity-associated FOXO3 genotype mitigates the risk of lung cancer after smoking cessation: a prospective cohort studyTranslational lung cancer research2026doi:10.21037/tlcr-2026-0267

1 of its findings points the other way.

1 lab in 1 country
1 finding against

Funders: National Heart, Lung, and Blood Institute and 3 more

Humans1

Effects

Lung cancer

no changein humans1

1 study

FOXO3GENOTYPE was not clearly linked with lung cancer in humans (current smokers).
“In contrast, no genotype-related differences were observed among current smokers.”
Humanscurrent smokersmales
Gene variant linked to lower lung cancer risk in former smokers
Translational lung cancer researchJun 10, 2026

Associations

Lung cancer

downin humans1HR 0.42

1 study

FOXO3GENOTYPE is linked with a lower risk of lung cancer in humans (former smokers; FOXO3-G carriers compared with FOXO3-TT carriers) (HR 0.42; 95% CI 0.23-0.79).
“Among former smokers, FOXO3-G carriers had a lower risk than FOXO3-TT carriers (LC: HR, 0.42; 95% CI, 0.23-0.79”
Humansformer smokers; FOXO3-G carriers compared with FOXO3-TT carriersmalesn = 4,339
Gene variant linked to lower lung cancer risk in former smokers
Translational lung cancer researchJun 10, 2026

Latest

1 paper in 12 months

Translational Lung Cancer ResearchAug 12

Gene variant linked to lower lung cancer risk in former smokers

Former smokers carrying a longevity-linked gene variant had lower relative lung cancer risk than noncarriers, with a hazard ratio of 0.42.Former smokers carrying a longevity-linked gene variant had lower relative lung cancer risk than noncarriers, with a hazard ratio of 0.42.

Cohort · 4,339 peopleLung cancer

Paper