folr-1

1. folr-1 impairs healthspan in worms.

   “overexpression of folr-1 is toxic, and that this phenotype is dependent on diet”

   Model organismsdiet-dependent

   Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans

   Scientific reports·Jan 11, 2024

1. folr-1 has no effect on lifespan in worms.

   “the loss of FOLR-1 does not affect reproduction, physical condition, proteostasis or lifespan”

   Model organismsloss of folr-1

   Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans

   Scientific reports·Jan 11, 2024

1. lin-53 inhibits folr-1 in worms.

   “histone-binding protein LIN-53 inhibits its expression in other tissues”

   Model organisms

   Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans

   Scientific reports·Jan 11, 2024

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