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flp-17

Gene

1 paper2 findings

Taxon 6239

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Model organisms1

Effects

2

Protein aggregation

downin worms1

1 study

  1. flp-17 protects against protein aggregation in worms.

    “FLP-17 is sufficient to protect against chronic ER stress and age-dependent protein aggregation.”

    Model organisms

    A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans

    bioRxiv : the preprint server for biology15 Mar 2025Preprint

ER unfolded protein response

upin worms1

1 study

  1. flp-17 activates ER unfolded protein response in worms.

    “identified a single neuropeptide, FLP-17, that is sufficient but not necessary to induce cell non-autonomous activation of the UPR ER .”

    Model organisms

    A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans

    bioRxiv : the preprint server for biology15 Mar 2025Preprint

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