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fbl-1

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Japan Society for the Promotion of Science and 1 more
  • Model organisms1

Effects

2

Lifespan

upin worms1

1 study

  1. fbl-1 extends lifespan in worms.

    “Interestingly, fbl-1(k206), but not fbl-1(k201) or let-2 alleles, exhibited an extended lifespan compared to the wild type when combined with mig-17.”

    Model organismscombined with mig-17 compared to wild type

    Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans

    PloS oneJul 9, 2024

Senescence defects

downin worms1

1 study

  1. fbl-1 decreases senescence defects in worms.

    “let-2(k196) fully and fbl-1(k201) partly, but not let-2(k193) and fbl-1(k206), suppressed the senescence defects of mig-17.”

    Model organismsin mig-17 mutants

    Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans

    PloS oneJul 9, 2024

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