EPRS

1. EPRS increases lipid and ceramide metabolism in mouse cells.

   “phospho-EPRS binds SLC27A1 (that is, fatty acid transport protein 1, FATP1), inducing its translocation to the plasma membrane and long-chain fatty acid uptake”

   Cellsin adipocytes

   EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

   Nature·8 Feb 2017

More on Lipid and ceramide metabolism

1. EPRS decreases adiposity in mice.

   “Homozygous S999A mice exhibited low body weight, reduced adipose tissue mass, and increased lifespan”

   Animalshomozygous S999A knock-in

   EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

   Nature·8 Feb 2017

1. EPRS extends lifespan in mice.

   “Homozygous S999A mice exhibited low body weight, reduced adipose tissue mass, and increased lifespan”

   Animalshomozygous S999A knock-in

   EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

   Nature·8 Feb 2017