There are 2 papers on EIF4E2 in aging research: none in people yet, 2 in animals.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Fundamental Research Funds for the Central Universities and 3 more
- Animals2
Effects
3Hypoxia-induced damage
downin zebrafish1
1 study
Hypoxia-induced damage
downin zebrafish1
EIF4E2 protects against hypoxia-induced damage in zebrafish under hypoxia.
“eIF4E2 isoforms with GSK3β-binding motif exclusively exist in mammals, which protect zebrafish heart against hypoxia.”
Animalsunder hypoxiaheart
Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
Cell death & disease
Mouse viability
upin mice1
1 study
Mouse viability
upin mice1
EIF4E2 improves mouse viability in mice under physiological hypoxia.
“eIF4E2-GSK3β is unique to mammals, which maintains mice viability and prevents liver senescence against physiological hypoxia.”
Animalsunder physiological hypoxia
Mammalian-unique eIF4E2 maintains GSK3β proline kinase activity to resist senescence against hypoxia
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Cellular senescence
downin animals1
1 study
Cellular senescence
downin animals1
EIF4E2 prevents cellular senescence.
“we identified a mammalian -unique eIF4E2-GSK3β pathway preventing senescence and guarding against hypoxia in vivo”
Animals
Mammalian-unique eIF4E2 maintains GSK3β proline kinase activity to resist senescence against hypoxia
bioRxiv (Cold Spring Harbor Laboratory)Preprint