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EHD2

There are 3 papers on EHD2 in aging research: none in people yet, 1 in animals, 2 in cells.

Gene

3 papers study it2 findings

HGNCNCBI GeneTaxon

See all 3 papers on EHD2

At a glance

The findings reach mice, none yet in people. 2 independent labs in 3 countries.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 3 countries
  • Funders: China Scholarship Council - University of Melbourne PhD Scholarship and 5 more
  • Animals1
  • Cells2

Effects

1

Ca2+ sparks

upin mice1

1 study

  1. EHD2 increases Ca2+ sparks in mice (shown by genetic abolition; present in young but not old mice).

    “genetic abolition of Eps15 homology domain-containing protein (EHD2) inhibited Ca2+ sparks in cells from young (4 months) but not old (12 months) mice”

    Animalsshown by genetic abolition; present in young but not old micevascular smooth muscle cells

    Age attenuates the T-type CaV 3.2-RyR axis in vascular smooth muscle

    Aging cell

Upstream

1

Cellular senescence

upin mouse cells1

1 study

  1. Cellular senescence increases EHD2 in senescent cells.

    “EHD2 was identified and validated as a novel protein that is enhanced at the cell surface of senescent MEFs.”

    Cellsin senescent cellscell surface

    Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome

    Analytical chemistry

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