What does the research say about DPPA3?

DPPA3

There are 3 papers on DPPA3 in aging research: none in people yet, 1 in animals, 2 in cells.

3 papers study it3 findings

The findings reach people, from one lab or study. 1 lab in 1 country.

None of its findings points the other way.

Cell culture

upin mouse cells1

1 study

Cell culture increases DPPA3 in mouse cells (cultured OSCs from aged females).
“once established the cultured cells reactivated Dppa3 expression and the capacity for oogenesis.”
Cellscultured OSCs from aged femalesoogonial stem cellsfemales
Characterization of Oogonial Stem Cells in Adult Mouse Ovaries with Age and Comparison to In Silico Data on Human Ovarian Aging
Stem cells and developmentJan 4, 2023

Chronological aging

downin humans1downin mice1

1 study

Chronological aging is linked with lower DPPA3 in humans.
“frequency of DPPA3-expressing cells decreased with advancing age, and this was paralleled by reduced expression of several key meiotic differentiation genes.”
Humansovaryfemales
Characterization of Oogonial Stem Cells in Adult Mouse Ovaries with Age and Comparison to In Silico Data on Human Ovarian Aging
Stem cells and developmentJan 4, 2023
Chronological aging decreases DPPA3 in mice.
“expression of developmental pluripotency associated 3 (Dppa3), an epigenetic modifier that promotes OSC differentiation into oocytes, was lost as the mice transitioned from a time of reproductive compromise (10 months) to reproductive failure (15 months).”
Animalsovaryfemales
Characterization of Oogonial Stem Cells in Adult Mouse Ovaries with Age and Comparison to In Silico Data on Human Ovarian Aging
Stem cells and developmentJan 4, 2023