AgingResearch.NewsJoin free

DACH1

Gene

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Deutsche Forschungsgemeinschaft and others
  • 1 of 3 findings with company ties
  • Humans1
  • Animals1

Effects

2

Trabecular bone formation

upin mice1

1 study

  1. DACH1 increases trabecular bone formation in mice.

    “enabling trabecular bone formation in normally highly hypoxic areas of the diaphysis”

    Animalsendothelial cell-specific overexpression of DACH1diaphysis

    Specialized post-arterial capillaries facilitate adult bone remodelling

    Nature cell biologyNov 11, 2024

Type R capillaries

upin mice1

1 study

  1. DACH1 increases type R capillaries in mice.

    “Endothelial cell-specific overexpression of the transcription factor DACH1 in postnatal mice induces a strong increase in arteries and type R capillaries”

    Animalsendothelial cell-specific overexpressionbone

    Specialized post-arterial capillaries facilitate adult bone remodelling

    Nature cell biologyNov 11, 2024

Associations

1

metabolic processes

upin humans1

1 study

  1. DACH1 is associated with metabolic processes in humans.

    “The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes.”

    Humansbrainn = 15,640

    Genetic variants associated with longitudinal changes in brain structure across the lifespan

    Nature neuroscienceApr 5, 2022

Latest

Related