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cact

Gene

2 papers study it4 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 2 more
  • Model organisms2

Effects

4

Body mass

downin T. castaneum1

1 study

  1. cact decreases body mass in T. castaneum.

    “However, these benefits were counterbalanced by dsRNA dose-dependent costs to lifespan, fecundity, body mass, and gut integrity.”

    Model organismsdsRNA dose-dependent

    Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    PLoS pathogensFeb 26, 2024

Fecundity

downin T. castaneum1

1 study

  1. cact decreases fecundity in T. castaneum.

    “However, these benefits were counterbalanced by dsRNA dose-dependent costs to lifespan, fecundity, body mass, and gut integrity.”

    Model organismsdsRNA dose-dependent

    Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    PLoS pathogensFeb 26, 2024

Lifespan

downin T. castaneum1

1 study

  1. cact shortens lifespan in T. castaneum.

    “However, these benefits were counterbalanced by dsRNA dose-dependent costs to lifespan, fecundity, body mass, and gut integrity.”

    Model organismsdsRNA dose-dependent

    Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    PLoS pathogensFeb 26, 2024

Bacterial infection

downin T. castaneum1

1 study

  1. cact protects against bacterial infection in T. castaneum.

    “Cactus knock-down increased the overall magintude of inducible immune responses and delayed their resolution in a dsRNA dose-dependent manner, promoting survival and resistance following bacterial infection.”

    Model organismsafter bacterial infectiondsRNA dose-dependent

    Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    bioRxiv : the preprint server for biologyAug 14, 2023Preprint

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