Communications Biology
Choline use supports leukemia progression in mice
Disrupting either of two choline-processing enzymes in transplanted human leukemia cells extended mice’s median survival to 95 or 90 days, versus 72 days in controls.Disrupting either of two choline-processing enzymes in transplanted human leukemia cells extended mice’s median survival to 95 or 90 days, versus 72 days in controls.
Mouse studyMechanisms
Who was studiedFemale NCG mice, against controls
What changedMedian survival was higher after enzyme disruption: 95 or 90 days versus 72 days in controls
The catchGene editing occurred before transplantation; treatment of established leukemia was not measured