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BACE1-AS

Gene

1 paper studies it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: Deutsche Forschungsgemeinschaft and 3 more
  • Humans1

Associations

3

BACE1

upin humans1

1 study

  1. BACE1-AS is associated with BACE1 in humans (r = 0.396, p < 0.001).

    “BACE1-AS expression correlated with BACE1 expression (r = 0.396, p < 0.001)”

    Humanspbmc

    Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

    Thrombosis and haemostasis

More on BACE1

Major adverse cardiovascular events

upin humans1HR 1.86

1 study

  1. BACE1-AS predicts major adverse cardiovascular events in humans (adjusted HR 1.86 per ascending tertile, 95% CI 1.011-3.43, p = 0.046).

    “BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011-3.43, p = 0.046).”

    Humansin high cardiovascular risk patients, adjustedmedian of 52 months

    Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

    Thrombosis and haemostasis

Coronary artery disease

upin humans1OR 1.85

1 study

  1. BACE1-AS is associated with coronary artery disease in humans (OR 1.85, 95% CI 1.37-2.5).

    “BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37-2.5)”

    Humansafter multivariable adjustment for traditional cardiovascular risk factors

    Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease

    Thrombosis and haemostasis

More on Coronary artery disease

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