ASH2L

1. ASH2L inhibits cellular senescence in cells.

   “Upon prolonged ASH2L loss, cells develop a senescent phenotype, a process linked to aging and disease.”

   Cellsshown by prolonged ASH2L loss

   Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells

   bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint

More on Cellular senescence

1. ASH2L increases H3K4me3 in cells.

   “We find that PROTAC induced depletion of ASH2L reduces H3K4me3, deregulates gene expression and prevents proliferation.”

   Cellsshown by PROTAC-induced ASH2L depletion

   Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells

   bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint

More on H3K4me3