AHNAK1

1. AHNAK1 impairs cardiac and skeletal muscle contractile function in mice.

   “Cardiomyocyte contractility and fatigue resistance of TA muscles were significantly increased in Ahnak1-KO mice of both sexes, compared with the WT groups”

   Animalsshown by knockoutheart and tibialis anterior

   Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression

   Journal of cachexia, sarcopenia and muscle·Jul 1, 2021

1. AHNAK1 decreases mitochondrial respiratory capacity in mice (P < 0.05 and P < 0.01).

   “The maximal and reserve respiratory capacities were significantly higher in cardiomyocytes from aged adult Ahnak1-KO mice compared with the WT counterparts”

   Animalsshown by knockoutcardiomyocytes

   Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression

   Journal of cachexia, sarcopenia and muscle·Jul 1, 2021

1. AHNAK1 decreases mitochondrial fission and fusion in mice (P < 0.01 and P < 0.001).

   “we observed a shift in mitochondrial fission/fusion balance towards fusion in cardiomyocytes and TA muscle from aged adult Ahnak1-KO mice”

   Animalsshown by knockoutleft ventricle and tibialis anterior

   Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression

   Journal of cachexia, sarcopenia and muscle·Jul 1, 2021

More on Mitochondrial fission and fusion

1. AHNAK1 impairs exercise tolerance in mice (100% Ahnak1-KO vs ~31% male and 8% female WT completed the running programme).

   “The suppression of Ahnak1 was associated with improved exercise tolerance”

   Animalsshown by knockout

   Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression

   Journal of cachexia, sarcopenia and muscle·Jul 1, 2021