There are 2 papers on ABLIM3 in aging research: 1 observational study in people, 1 in animals.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of Child Health and Human Development and 2 more
- Humans1
- Animals1
Effects
3Remote fear memory generalization
upin rodents1
1 study
Remote fear memory generalization
upin rodents1
ABLIM3 increases remote fear memory generalization in rodents (shown by ABLIM3 knockdown in dentate granule cells).
“decreased fear memory generalization at remote (i.e., distal) time points.”
Animalsshown by ABLIM3 knockdown in dentate granule cellsremote time points
Nature medicine
Fear memory engram maintenance
downin rodents1
1 study
Fear memory engram maintenance
downin rodents1
ABLIM3 impairs fear memory engram maintenance in rodents (shown by ABLIM3 knockdown in dentate granule cells).
“maintain a fear memory engram in the DG over time.”
Animalsshown by ABLIM3 knockdown in dentate granule cellsdentate gyrus
Nature medicine
feedforward inhibition onto CA3
downin rodents1
1 study
feedforward inhibition onto CA3
downin rodents1
ABLIM3 inhibits feedforward inhibition onto CA3 in rodents (shown by ABLIM3 knockdown in dentate granule cells).
“enhance feedforward inhibition onto CA3”
Animalsshown by ABLIM3 knockdown in dentate granule cellshippocampal CA3
Nature medicine