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Severe metabolic dysfunction-associated steatotic liver disease

Disease

1 paper3 findings

  • Humans1

Associations

3

Biological age acceleration and polygenic risk score

upin humans1

1 study

  1. Biological age acceleration and polygenic risk score is associated with severe metabolic dysfunction-associated steatotic liver disease in humans.

    “individuals with the highest BA acceleration and PRS had the highest risk of developing severe MASLD”

    HumansHighest biological age acceleration and highest polygenic risk scoren = 347,917

    Accelerated biological aging, genetic susceptibility, and incident severe MASLD, liver cirrhosis and cancer

    Research Square10 Apr 2024Preprint

More on Biological age acceleration and polygenic risk score

PhenoAgeAccel

upin humans1+10% higher masld risk per sd increase

1 study

  1. PhenoAgeAccel is associated with severe metabolic dysfunction-associated steatotic liver disease in humans (10% higher MASLD risk per SD increase).

    “Each SD increase in KDM-BAaccel and PhenoAgeAccel was correlated with an 10% elevated risk of MASLD.”

    HumansPer SD increase in PhenoAgeAcceln = 347,917

    Accelerated biological aging, genetic susceptibility, and incident severe MASLD, liver cirrhosis and cancer

    Research Square10 Apr 2024Preprint

More on PhenoAgeAccel

KDM-BAaccel

upin humans1+10% higher masld risk per sd increase

1 study

  1. KDM-BAaccel is associated with severe metabolic dysfunction-associated steatotic liver disease in humans (10% higher MASLD risk per SD increase).

    “Each SD increase in KDM-BAaccel and PhenoAgeAccel was correlated with an 10% elevated risk of MASLD.”

    HumansPer SD increase in KDM-BAacceln = 347,917

    Accelerated biological aging, genetic susceptibility, and incident severe MASLD, liver cirrhosis and cancer

    Research Square10 Apr 2024Preprint

More on KDM-BAaccel

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