Progression to sustained mild cognitive impairment

1. Driving-trajectory markers predict progression to sustained mild cognitive impairment in humans (HR 6.02, 95% CI 2.35–15.41).

   “Driving markers stratified risk at 12 months (HR = 6.02, 95%CI: 2.35-15.41) and 24 months (HR = 13.38, 95%CI: 3.03-59.04).”

   Humanslandmark survival analysis12 months

   Driving changes linked to later cognitive decline in older adults

   The journals of gerontology. Series B, Psychological sciences and social sciences·Oct 19, 2026

More on Driving-trajectory markers

1. driving-trajectory prediction model predicts progression to sustained mild cognitive impairment in humans (AUC 0.752 (95% CI 0.627–0.863); 76% sensitivity; 75% specificity; 18-month median lead time).

   “The model detected 19/25 progressors (AUC=0.752, 95%CI: 0.627-0.863; 76% sensitivity; 75% specificity) with an 18-month median lead time before sustained CDR conversion.”

   Humansinitially cognitively normaln = 298

   Driving changes linked to later cognitive decline in older adults

   The journals of gerontology. Series B, Psychological sciences and social sciences·Oct 19, 2026