Primary aldosteronism
Disease2 papers5 findings
One human study associates primary aldosteronism with lower potassium and higher frequencies of obstructive sleep apnoea, stroke and left ventricular hypertrophy in adults with low-grade hypertension.
- Humans1
Associations
5Potassium
downin humans1
1 study
Potassium
downin humans1
Primary aldosteronism is associated with potassium in humans (3.42 vs 4.13 mEq/L).
Humansin adults with low-grade hypertension
Observed frequency of primary aldosteronism among adults with low-grade hypertension in routine outpatient practice · Medical journal, Armed Forces India · 11 Mar 2026
Obstructive sleep apnea
upin humans1
1 study
Obstructive sleep apnea
upin humans1
Primary aldosteronism is associated with obstructive sleep apnea in humans (20.9% vs 2.5%).
Humansin adults with low-grade hypertension
Observed frequency of primary aldosteronism among adults with low-grade hypertension in routine outpatient practice · Medical journal, Armed Forces India · 11 Mar 2026
Stroke
upin humans1
1 study
Stroke
upin humans1
Primary aldosteronism is associated with stroke in humans (16.7% vs 1.8%).
Humansin adults with low-grade hypertension
Observed frequency of primary aldosteronism among adults with low-grade hypertension in routine outpatient practice · Medical journal, Armed Forces India · 11 Mar 2026
Left ventricular hypertrophy
upin humans1
1 study
Left ventricular hypertrophy
upin humans1
Primary aldosteronism is associated with left ventricular hypertrophy in humans (58.3% vs 20.2%).
Humansin adults with low-grade hypertension
Observed frequency of primary aldosteronism among adults with low-grade hypertension in routine outpatient practice · Medical journal, Armed Forces India · 11 Mar 2026
Hypertension
upin humans1
1 study
Hypertension
upin humans1
Hypertension is associated with primary aldosteronism in humans (8.0% (24/300)).
Humansin routine outpatients with low-grade hypertensionn = 300
Observed frequency of primary aldosteronism among adults with low-grade hypertension in routine outpatient practice · Medical journal, Armed Forces India · 11 Mar 2026
Trial sponsors
2 trialsPhase 4366 people
Nanjing University School of Medicine
2 trialsPhase 4151 people
Shanghai Jiao Tong University School of Medicine
1 trialPhase 4150 people
University Hospital, Basel, Switzerland
1 trialPhase 212 people
University Medical Center Groningen
1 trialPhase 1/212 people
Funding
National Heart, Lung, and Blood InstituteUS$893.6kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$748.5k3 grants since 2018
Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes
National Institute of Diabetes and Digestive and Kidney DiseasesBrigham and Women's HospitalUS$748.5k2018–2029
Understanding and addressing the lack of and delayed screening for primary Aldosteronism
National Heart, Lung, and Blood InstituteMayo Clinic RochesterUS$700.7k2025–2028
Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum
National Heart, Lung, and Blood InstituteBrigham and Women's HospitalUS$192.9k2022–2027