Periprosthetic joint infection

1. GLP-1 receptor agonists lower the risk of periprosthetic joint infection in humans (RR 0.74, 95% CI 0.57, 0.96).

   Humansfollowing total knee arthroplastyknee joint2 years

   Glucagon-like Peptide-1 receptor agonist use is associated with decreased risk of periprosthetic joint infection following total knee arthroplasty: A laterality-verified propensity matched comparison · Journal of orthopaedic surgery (Hong Kong) · 6 Sep 2026

GLP-1 receptor agonists →

1. Tirzepatide lowers the risk of periprosthetic joint infection in humans (OR 0.64, 95% CI 0.41 to 0.999).

   Humanscompared with semaglutide after primary TKA or THA2 years

   Dual GIP/GLP-1 Receptor Agonist Versus Selective GLP-1 Receptor Agonist in Patients Undergoing Primary Total Knee or Hip Arthroplasty · Research Square · 4 Sep 2026 · Preprint

Tirzepatide →